Cryptotanshinone

Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions. Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells. It inhibits the protein tyrosine phosphatase SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells. Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis. However, it is poorly absorbed and has low bioavailability in vivo.Formal Name: (1R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro[1,2-b]furan-10,11-dione. CAS Number: 35825-57-1. Molecular Formula: C19H20O3. Formula Weight: 296.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 0.25 mg/ml. lambdamax: 220, 264, 271, 361, 439 nm. SMILES: O=C(C1=O)C2=C(OC[C@@H]2C)C3=C1C(CCCC4(C)C)=C4C=C3. InChi Code: InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1. InChi Key: GVKKJJOMQCNPGB-JTQLQIEISA-N.