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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
LKT-C5863.1 | 1 mg | - |
3 - 8 business days* |
69.00€
|
|||
LKT-C5863.5 | 5 mg | - |
3 - 8 business days* |
201.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Coptisine is an isoquinoline alkaloid originally isolated from a variety of sources, including... more
Product information "Coptisine Hydrochloride"
Coptisine is an isoquinoline alkaloid originally isolated from a variety of sources, including species of Fumeria and Papavera. Coptisine exhibits a wide variety of beneficial properties, including cardioprotective, anti-inflammatory, neuromodulatory, antibacterial, and chemotherapeutic activities. Coptisine attenuates mitochondrial respiratory dysfunction, inhibits expression of RhoA/ROCK, and decreases myocardial apoptosis. Coptisine also inhibits proliferation of vascular smooth muscle cells, potentially through upregulation of Gadd45a and Rgc32 genes. Coptisine induces cell cycle arrest in vascular smooth muscle cells as well, decreasing levels of cyclin D1 and potentially inhibiting tubulin polymerization. In heart tissue, this compound inhibits expression of IL-6, TNF-alpha, and IL-1beta, displaying cardioprotective benefit in animal models of ischemia/reperfusion. Coptisine inhibits proliferation in cancer cell lines. This compound also inhibits monoamine oxidase A (MAO-A) and exhibits antibiotic activity against gram negative bacteria Escherischia coli.
Supplier: | LKT Laboratories |
Supplier-Nr: | C5863 |
Properties
MW: | 355.77 D |
Format: | Solid |
Database Information
CAS : | 6020-18-4| Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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