Clioquinol

Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties. It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively. Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the alpha-synuclein hA53T transgenic mouse model of Parkinson's disease. It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.Formal Name: 5-chloro-7-iodo-8-quinolinol. CAS Number: 130-26-7. Synonyms: Iodochlorohydroxyquin, NSC 3531, NSC 74938. Molecular Formula: C9H5ClINO. Formula Weight: 305.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:8): 0.5 mg/ml. lambdamax: 255, 324 nm. SMILES: OC1=C2C(C=CC=N2)=C(Cl)C=C1I. InChi Code: InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H. InChi Key: QCDFBFJGMNKBDO-UHFFFAOYSA-N.