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Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine, the major phospholipid in eukaryotic cells. It also serves as a choline donor in the biosynthesis of the neurotransmitter acetylcholine. Citicholine demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Exogenous administration of citicholine to rodents (500 mg/kg i.p. immediately after ischemia and at 3-h reperfusion) has been shown to stimulate the synthesis of phosphatidylcholine, sphingomyelin, and cardiolipin and to attenuate the release of arachidonic acid and the accumulation of ceramide.Formal Name: P'-[2-(trimethylammonio)ethyl] ester-cytidine 5'-(trihydrogen diphosphate)-inner, monosodium salt. CAS Number: 33818-15-4. Synonyms: Cytidine 5'-diphosphocholine, Flussorex, Gerolin, Logan, Neurotron, Sinkron. Molecular Formula: C14H25N4O11P2 . Na. Formula Weight: 510.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 274 nm. SMILES: O=P(OP(OCC[N+](C)(C)C)([O-])=O)([O-])OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)[C@H](O)[C@@H]1O.[Na+]. InChi Code: InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21,/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25),/q,+1/p-1/t9-,11-,12-,13-,/m1./s1. InChi Key: YWAFNFGRBBBSPD-OCMLZEEQSA-M.
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