CID-2858522

CID-2858522 is an 2-amino benzimidazole that inhibits activation of the NF-kappaB pathway induced by the PKC activator PMA with an IC50 value of 0.07 µM. It has been shown to inhibit IL-8 production induced by PKC activators in HEK293 cells (IC50 = 0.1 µM), attenuate CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T cells (IC50 = 5 µM), and prevent anti-IgM-stimulated proliferation of mouse B-lymphocytes (IC50 = ~2 µM). CID-2858522 does not, however, inhibit the NF-kappaB pathway activated by TNF-alpha.Formal Name: 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone. CAS Number: 758679-97-9. Synonyms: ML-029. Molecular Formula: C28H39N3O3. Formula Weight: 465.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 215, 254, 292 nm. SMILES: CC1=C(C)C=C(N(CC(C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)=O)C(NCCCO)=N3)C3=C1. InChi Code: InChI=1S/C28H39N3O3/c1-17-12-22-23(13-18(17)2)31(26(30-22)29-10-9-11-32)16-24(33)19-14-20(27(3,4)5)25(34)21(15-19)28(6,7)8/h12-15,32,34H,9-11,16H2,1-8H3,(H,29,30). InChi Key: CYCGGKILBWERDJ-UHFFFAOYSA-N.