Chlorpropamide

Chlorpropamide is a first generation sulfonylurea. It increases glycolysis by increasing fructose-2,6-bisphosphate levels and inhibits glucagon-induced gluconeogenesis by augmenting the effect of insulin in isolated rat hepatocytes when used at a concentration of 0.2 mM. Chlorpropamide reverses increases in blood glucose levels induced by hydrochlorothiazide (Cay-21304) and previous insulin in a rabbit model of diabetes when administered in a single 250 mg/kg dose or repeated doses of 10 mg/kg per day for six days. Formulations containing chlorpropamide have been used as adjuncts to diet and exercise in the treatment of type 2 diabetes.Formal Name: 4-chloro-N-[(propylamino)carbonyl]-benzenesulfonamide. CAS Number: 94-20-2. Synonyms: NSC 44634, NSC 626720. Molecular Formula: C10H13ClN2O3S. Formula Weight: 276.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetone: soluble, Chloroform: soluble, Ethanol: soluble. lambdamax: 232 nm. SMILES: ClC1=CC=C(S(NC(NCCC)=O)(=O)=O)C=C1. InChi Code: InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14). InChi Key: RKWGIWYCVPQPMF-UHFFFAOYSA-N.