Chamazulene

Chamazulene is a terpene that has been found in chamomile (M. recutita) flowers and has anti-inflammatory and antioxidant activities. It reduces increases in matrix metalloproteinase-3 (MMP-3), MMP-9, COX-2, inducible nitric oxide synthase (iNOS), and p65 NF-kappaB levels in IL-1beta-stimulated primary rat chondrocytes when used at a concentration of 10 µg/ml. Chamazulene (10 and 20 µg/ml) reduces IL-1beta-induced production of malondialdehyde (MDA) and increases levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) in primary rat chondrocytes. In vivo, chamazulene (25 and 50 mg/kg) reduces hind paw volume, serum levels of MDA, TNF-alpha, and IL-6, and cartilage erosion in a rat model of osteoarthritis induced by complete Freund's adjuvant (CFA).Formal Name: 7-ethyl-1,4-dimethyl-azulene. CAS Number: 529-05-5. Synonyms: Dimethulene. Molecular Formula: C14H16. Formula Weight: 184.3. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: soluble, Water: very slightly soluble. lambdamax: 245, 285, 289 nm. SMILES: CCC1=CC=C(C)C2=CC=C(C)C2=C1. InChi Code: InChI=1S/C14H16/c1-4-12-7-5-10(2)13-8-6-11(3)14(13)9-12/h5-9H,4H2,1-3H3. InChi Key: GXGJIOMUZAGVEH-UHFFFAOYSA-N. Origin: Natural/Source unknown.