CCG-50014

CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Galpha subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Galpha0, while blocking GTPase activity and Galpha0-dependent translocation of RGS4 to the membrane.Formal Name: 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione. CAS Number: 883050-24-6. Molecular Formula: C16H13FN2O2S. Formula Weight: 316.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/mL, DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL, DMSO: 10 mg/mL, Ethanol: 1 mg/mL. lambdamax: 251 nm. SMILES: CC1=CC=C(N2SC(N(CC3=CC=C(F)C=C3)C2=O)=O)C=C1. InChi Code: InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3. InChi Key: QUIIIYITNGOFEI-UHFFFAOYSA-N.