CAY10784

CAY10784 is a STAT3 inhibitor (IC50 = 0.74 µM in a reporter assay) and a derivative of WP1066 (Cay-14736). It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 µM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 µM for both). CAY10784 is also active against H. pylori and C. jejuni (MICs = 1.6 and 4.7 µM, respectively).Formal Name: N-(5-nitro-2-thiazolyl)-4-(trifluoromethyl)-benzamide. CAS Number: 1245814-52-1. Molecular Formula: C11H6F3N3O3S. Formula Weight: 317.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 232, 342 nm. SMILES: O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC=C([N+]([O-])=O)S2. InChi Code: InChI=1S/C11H6F3N3O3S/c12-11(13,14)7-3-1-6(2-4-7)9(18)16-10-15-5-8(21-10)17(19)20/h1-5H,(H,15,16,18). InChi Key: HKCGJKNZQDBZFT-UHFFFAOYSA-N.