CAY10781

CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A. It inhibits the interaction by 43% when used at a concentration of 12.5 µM. CAY10781 also inhibits VEGF-A-induced phosphorylation of VEGFR2 in catecholamine A-differentiated (CAD) cells when used at the same concentration.Formal Name: 3,4-dihydro-4-oxo-2-(3-pyridinyl)-5-pyrimidineacetic acid. CAS Number: 1210360-87-4. Molecular Formula: C11H9N3O3. Formula Weight: 231.2. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMF: insol, DMSO: 10 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 288 nm. SMILES: O=C(CC1=CN=C(C2=CN=CC=C2)NC1=O)O. InChi Code: InChI=1S/C11H9N3O3/c15-9(16)4-8-6-13-10(14-11(8)17)7-2-1-3-12-5-7/h1-3,5-6H,4H2,(H,15,16)(H,13,14,17). InChi Key: PQXHMOPMDOFJHD-UHFFFAOYSA-N.