CAY10773

CAY10773 is a derivative of the ferroptosis inducer sorafenib (Cay-10009644). It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 µM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 µM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (>6 µM) also induces autophagy with incubation times longer than eight hours.Formal Name: N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]-urea. CAS Number: 1648546-79-5. Molecular Formula: C22H17Cl2N5O. Formula Weight: 438.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml. lambdamax: 264 nm. SMILES: O=C(NC1=CC=C(C(Cl)=C1)Cl)NC2=CC=CC(CNC3=C4C=CC=CC4=NC=N3)=C2O=C(NC1=CC=C(C(Cl)=C1)Cl)NC2=CC=CC(CNC3=C4C=CC=CC4=NC=N3)=C2. InChi Code: InChI=1S/C22H17Cl2N5O/c23-18-9-8-16(11-19(18)24)29-22(30)28-15-5-3-4-14(10-15)12-25-21-17-6-1-2-7-20(17)26-13-27-21/h1-11,13H,12H2,(H,25,26,27)(H2,28,29,30). InChi Key: UFOVWAAXBJCADF-UHFFFAOYSA-N.