CAY10654

The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR. It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 µM) without concurrent cytotoxicity. LasR is not induced by 100 µM CAY10654, although LasR is potently induced by natural AHL (5 µM) in positive control experiments.Formal Name: N1-(5-chloro-2-hydroxyphenyl)-N3-octyl-propanediamide. CAS Number: 1298023-69-4. Molecular Formula: C17H25ClN2O3. Formula Weight: 340.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 213, 247, 296 nm. SMILES: ClC1=CC=C(O)C(NC(CC(NCCCCCCCC)=O)=O)=C1. InChi Code: InChI=1S/C17H25ClN2O3/c1-2-3-4-5-6-7-10-19-16(22)12-17(23)20-14-11-13(18)8-9-15(14)21/h8-9,11,21H,2-7,10,12H2,1H3,(H,19,22)(H,20,23). InChi Key: VATFNKWOWBWJKB-UHFFFAOYSA-N.