CAY10647

CAY10647 is an aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg). This compound also binds to tubulin (Ki = 3.4 µM) and prevents tubulin polymerization.Formal Name: (4-fluorophenyl)(2-(4-methoxyphenyl)-1H-imidazol-4-yl)methanone. CAS Number: 1253697-49-2. Molecular Formula: C17H13FN2O2. Formula Weight: 296.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml. lambdamax: 258, 325 nm. SMILES: COC1=CC=C(C2=NC(C(C3=CC=C(F)C=C3)=O)=CN2)C=C1. InChi Code: InChI=1S/C17H13FN2O2/c1-22-14-8-4-12(5-9-14)17-19-10-15(20-17)16(21)11-2-6-13(18)7-3-11/h2-10H,1H3,(H,19,20). InChi Key: VKXVLHQVMBNLHX-UHFFFAOYSA-N.