CAY10565

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10565 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of 130 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 71% and 44% at pH 6.0 and 7.4, respectively.Formal Name: 4-methoxy-4-phenyl-1,3,2-oxathiazolidine-5-one. Synonyms: 4-(p-methoxyphenyl)-1,3,2-Oxathiazolylium-5-olate. Molecular Formula: C9H9NO3S. Formula Weight: 211.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 202, 268, 436 nm. SMILES: COc1ccc(cc1)C1[S]=NOC1O. InChi Code: InChI=1S/C9H9NO3S/c1-12-7-4-2-6(3-5-7)8-9(11)13-10-14-8/h2-5,8-9H,1H3. InChi Key: OUCJPOXOGCRTEY-UHFFFAOYSA-N.