CAY10562

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10562 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of 6 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 35% and 8% at pH 6.0 and 7.4, respectively.Formal Name: 4-phenyl-1,3,2-oxathiazol-3-ium-5-olate. Synonyms: 4-phenyl-1,3,2-Oxathiazolidine-5-one, 4-phenyl-1,3,2-Oxathiazolylium-5-olate. Molecular Formula: C8H7NO2S. Formula Weight: 181.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 202, 256, 409 nm. SMILES: [O-]C1=C([S+]=NO1)C2=CC=CC=C2. InChi Code: InChI=1S/C8H5NO2S/c10-8-7(12-9-11-8)6-4-2-1-3-5-6/h1-5H. InChi Key: LIAZLXDEPKYEDN-UHFFFAOYSA-N.