CAY10512

The nuclear factor-kappaB (NF-kappaB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-kappaB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFalpha-induced activation of NF-kappaB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.Formal Name: 1-fluoro-2-[2-(4-methoxyphenyl)ethenyl]-benzene. CAS Number: 139141-12-1. Molecular Formula: C15H13FO. Formula Weight: 228.3. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 229, 318 nm. SMILES: COc1ccc(cc1)\C=C/c1ccccc1F. InChi Code: InChI=1S/C15H13FO/c1-17-14-10-7-12(8-11-14)6-9-13-4-2-3-5-15(13)16/h2-11H,1H3/b9-6+. InChi Key: ILVFNAZMSMNXJG-RMKNXTFCSA-N.