CAY10441

CAY10441 is an antagonist of the IP receptor. It is selective for the IP receptor over the prostaglandin E2 (PGE2) receptor subtypes EP1, EP2, EP3, and EP4, the FP and TP receptors, and a panel of 30 other receptors and ion channels but does bind to the alpha2A-adrenergic and imidazoline I2 receptors. CAY10441 inhibits carbaprostacyclin-induced cAMP accumulation in SH-SY5Y cells (pKB = 8.8) and vasorelaxation of isolated human pulmonary arteries induced by the IP receptor agonist cicaprost (Cay-16831, pA2 = 8.2). It also decreases cicaprost-induced inhibition of platelet aggregation in human platelet-rich plasma. CAY10441 reduces acetic acid-induced writhing and carrageenan-induced paw hyperalgesia in rats (ED50s = 4 and 2.8 mg/kg, respectively).Formal Name: 4,5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imadazol-2-amine. CAS Number: 221529-58-4. Synonyms: Ro 1138452. Molecular Formula: C19H23N3O. Formula Weight: 309.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2)(1:10): 0.05 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 232 nm. SMILES: CC(C)Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1. InChi Code: InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22). InChi Key: GYYRMJMXXLJZAB-UHFFFAOYSA-N.