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Carmustine is a DNA alkylating agent. It inhibits cell growth and induces cell cycle arrest at the G2/M phase in C6 rat glioma cells when used at a concentration of 10 µM. In vivo, carmustine (0.3 and 6.7 mg/kg per day) reduces tumor growth in a C6 rat glioma model. Carmustine (0.5 mg/kg, i.p.) also reduces the number of amyloid-beta plaques and brain levels of amyloid-beta (1-40) (Abeta40), as well as increases brain levels of soluble amyloid precursor protein (sAPP) in the APP/PS1 transgenic mouse model of Alzheimer's disease. Formulations containing carmustine have been used in the treatment of gliomas and glioblastomas.Formal Name: N,N'-bis(2-chloroethyl)-N-nitroso-urea. CAS Number: 154-93-8. Synonyms: BCNU, bis-Chloroethylnitrosourea, NSC 409962. Molecular Formula: C5H9Cl2N3O2. Formula Weight: 214.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM, Water: 25 mM. lambdamax: 231 nm. SMILES: ClCCNC(N(N=O)CCCl)=O. InChi Code: InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11). InChi Key: DLGOEMSEDOSKAD-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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