BYK 191023 (hydrochloride)

BYK 191023 is an L-arginine competitive and selective inhibitor of inducible nitric oxide synthase (iNOS) with IC50 values of 0.086, 17, and 162 µM for human recombinant iNOS, nNOS, and eNOS, respectively. It also inhibits murine recombinant iNOS (IC50 = 95 nM). BYK 191023 inhibits iNOS-induced nitrite generation in RMC, RAW, and HEK293 cells (IC50s = 33, 3.1, and 13 µM, respectively). In vivo, BYK 191023 suppresses LPS-induced increases in plasma nitrate and nitrite levels in rats (ED50 = 14.9 µmol/kg per hour). It prevents development of delayed hypotension in a rat model of LPS-induced endotoxemia when administered at a dose of 50 µmol/kg per hour. BYK 191023 also increases mean arterial pressure and renal blood flow in a sheep model of septic shock.Formal Name: 2-[2-(4-methoxy-2-pyridinyl)ethyl]-3H-imidazo[4,5-b]pyridine, dihydrochloride. CAS Number: 1216722-25-6. Molecular Formula: C14H14N4O . 2HCl. Formula Weight: 327.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 100 mM. SMILES: COC1=CC=NC(CCC2=NC3=NC=CC=C3N2)=C1.Cl.Cl. InChi Code: InChI=1S/C14H14N4O.2ClH/c1-19-11-6-8-15-10(9-11)4-5-13-17-12-3-2-7-16-14(12)18-13,,/h2-3,6-9H,4-5H2,1H3,(H,16,17,18),2*1H. InChi Key: ZVNITETZYOKESF-UHFFFAOYSA-N.