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BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP, IC50s = 0.09-1.7 µM). It facilitates the oxidation of the catalytic cysteine residue by hydrogen peroxide. Similarly, it inhibits redox-sensitive cytochrome P450 (CYP) isoforms, including CYP2C19 and CYP2D6, with IC50 values less than 10 µM. BVT 948 also inhibits the protein methyltransferases SETD8, SETD2, G9a, SMYD2, CARM1, and PRMT3 with IC50 values from 0.7 to 3.2 µm. Presumably through its effects on PTPs, BVT 948 enhances insulin signaling in cells and insulin tolerance in ob/ob mice, suppresses the expression of matrix metalloproteinase-9 and invasion in breast cancer cells, and increases NMDA-induced substance P release by spinal cord slices.Formal Name: 4-hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione. CAS Number: 39674-97-0. Molecular Formula: C14H11NO3. Formula Weight: 241.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 50 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 225, 270, 460 nm. SMILES: O=C(C1=C2C=CC=C1)C(O)=C3C2=NC(C3(C)C)=O. InChi Code: InChI=1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3. InChi Key: BAQXWJQSUXZVIP-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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