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Borofalan is a radiation sensitizer that contains 10B, a stable isotope of boron. It sensitizes B16/F10 melanoma cells to fast and thermal neutron radiation when used at a concentration of 50 µg/ml. Borofalan (300 mg/kg) selectively accumulates in sarcoma tissues over blood, muscle, skin, liver, and brain tissue in rats. In vivo, borofalan (803 mg/kg), in combination with radiation, increases mean survival time in an F98 rat glioma model. Formulations containing borofalan have been used in boron neutron capture therapy (BNCT) of unresectable, locally recurrent head and neck cancer.Formal Name: 4-(borono-10B)-L-phenylalanine. CAS Number: 80994-59-8. Synonyms: Boronophenylalanine B-10, 10B-L-BPA. Molecular Formula: C9H12[10B]NO4. Formula Weight: 208.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, Water: Slightly soluble. SMILES: N[C@H](C(O)=O)CC(C=C1)=CC=C1[10B](O)O. InChi Code: InChI=1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1/i10-1. InChi Key: NFIVJOSXJDORSP-ULMHTEDTSA-N.
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