BMS-911543

BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively. It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM). BMS-911543 exhibited limited activity in a mouse model of JAK2V617F-driven myeloproliferative neoplasm.Formal Name: N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide. CAS Number: 1271022-90-2. Molecular Formula: C23H28N8O. Formula Weight: 432.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): slightly. lambdamax: 227, 280, 342 nm. SMILES: CN1C=NC2=C1C(C=C(C(N(C3CC3)C4CC4)=O)N5CC)=C5N=C2NC6=NN(C)C(C)=C6. InChi Code: InChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27). InChi Key: JCINBYQJBYJGDM-UHFFFAOYSA-N.