BMS 470539 (hydrochloride)

BMS 470539 is an agonist of melanocortin receptor 1 (MC1R). It induces cAMP accumulation in B16/F10 murine melanoma cells and in CHO cells overexpressing human MC1R (EC50s = 11.6 and 16.8 nM, respectively). It inhibits TNF-alpha-induced NF-kappaB activation in vitro in a concentration-dependent manner. In vivo, BMS 470539 inhibits LPS-induced TNF-alpha production in mice (ED50 = 10 µmol/kg, s.c.). It reduces LPS-induced leukocyte infiltration and paw swelling in mouse models of lung inflammation and delayed-type hypersensitivity, respectively. BMS 470539 decreases retinal damage in a mouse model of streptozotocin-induced diabetic retinopathy. It also increases striatal dopamine levels and decreases the number of striatal alpha-synuclein aggregates in a mouse model of Parkinson's disease when administered at a dose of 20 mg/kg.Formal Name: 1-[1-(3-methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone, dihydrochloride. CAS Number: 2341796-82-3. Molecular Formula: C32H41N5O4 . 2HCl. Formula Weight: 632.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 273 nm. SMILES: O=C([C@@H](CC1=CC=C(OC)C=C1)NC([C@@H](N)CC2=CN=CN2C)=O)N3CCC(C4=CC=CC=C4)(C(CCC)=O)CC3.Cl.Cl. InChi Code: InChI=1S/C32H41N5O4.2ClH/c1-4-8-29(38)32(24-9-6-5-7-10-24)15-17-37(18-16-32)31(40)28(19-23-11-13-26(41-3)14-12-23)35-30(39)27(33)20-25-21-34-22-36(25)2,,/h5-7,9-14,21-22,27-28H,4,8,15-20,33H2,1-3H3,(H,35,39),2*1H/t27-,28+,,/m0../s1. InChi Key: DUAOBJHRUKFKIH-YDVFRNEYSA-N.