BMS 189961

BMS 189961 is an agonist of retinoic acid receptor gamma (RARgamma, EC50 = 30 nM in a transactivation assay). It is selective for RARgamma over RARbeta (EC50 = 1,000 nM). In vitro, BMS 189961 decreases long bone growth and digit formation of isolated mouse embryonic limb buds when used at concentrations of 0.01 and 0.1 µM. Topical administration of BMS 189661 (40 nmol) increases the skin expression of retinoid metabolism-related genes, including Rdh10, Crabp2, and Krt4, as well as epidermal barrier genes, including Spink5, Klk5, and Klk7, in mice.Formal Name: 3-fluoro-4-[[2-hydroxy-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)acetyl]amino]benzoic acid. CAS Number: 185629-22-5. Synonyms: BMS 961. Molecular Formula: C23H26FNO4. Formula Weight: 399.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 268 nm. SMILES: OC(C1=CC(F)=C(NC(C(O)C2=CC(C(C)(C)CCC3(C)C)=C3C=C2)=O)C=C1)=O. InChi Code: InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29). InChi Key: AANFHDFOMFRLLR-UHFFFAOYSA-N.