Bisdemethoxycurcumin

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1alpha,25-dihydroxy vitamin D3 to stimulate amyloid-beta clearance by macrophages (optimal stimulation at 100 nM BDMC). More stable than curcumin in physiological media, BDMC suppresses proliferation in cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/beta-catenin pathway, and inhibits LPS induction of iNOS expression.Formal Name: 1,7-bis(4-hydroxyphenyl)-1E,6E-heptadiene-3,5-dione. CAS Number: 33171-05-0. Synonyms: BDMC. Molecular Formula: C19H16O4. Formula Weight: 308.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 419 nm. SMILES: OC1=CC=C(/C=C/C(CC(/C=C/C2=CC=C(O)C=C2)=O)=O)C=C1. InChi Code: InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+. InChi Key: PREBVFJICNPEKM-YDWXAUTNSA-N.