BIBB 515

2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.Formal Name: 1-(4-chlorobenzoyl)-4-[[4-(4,5-dihydro-2-oxazolyl)phenyl]methylene]-piperidine. CAS Number: 156635-05-1. Molecular Formula: C22H21ClN2O2. Formula Weight: 380.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.30 mg/ml, DMSO: 0.25 mg/ml, Ethanol: 0.15 mg/ml. SMILES: Clc1ccc(cc1)C(=O)N1CCC(=Cc2ccc(cc2)C2=NCCO2)CC1. InChi Code: InChI=1S/C22H21ClN2O2/c23-20-7-5-19(6-8-20)22(26)25-12-9-17(10-13-25)15-16-1-3-18(4-2-16)21-24-11-14-27-21/h1-8,15H,9-14H2. InChi Key: JQNWPWUJMRAASQ-UHFFFAOYSA-N.