Bialaphos (sodium salt)

Bialaphos is a natural non-selective phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog. L-Phosphinothricin inhibits glutamine synthetase (Ki = 6.1 µM), resulting in accumulation of ammonium and disruption of primary metabolism. The bacterial bar gene encodes a phosphinothricin acetyltransferase, which confers resistance to phosphinothricin. Bialaphos is used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.Formal Name: 2S-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine, monosodium salt. CAS Number: 71048-99-2. Synonyms: SF 1293. Molecular Formula: C11H21N3O6P . Na. Formula Weight: 345.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: [O-]C([C@H](C)NC([C@H](C)NC([C@@H](N)CCP(C)(O)=O)=O)=O)=O.[Na+]. InChi Code: InChI=1S/C11H22N3O6P.Na/c1-6(9(15)14-7(2)11(17)18)13-10(16)8(12)4-5-21(3,19)20,/h6-8H,4-5,12H2,1-3H3,(H,13,16)(H,14,15)(H,17,18)(H,19,20),/q,+1/p-1/t6-,7-,8-,/m0./s1. InChi Key: RTWIRLHWLMNVCC-WQYNNSOESA-M.