BI-2536

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
BPS-82062-1	25 mg		-	-	3 - 15 business days*		1,204.00€
BPS-82062-2	50 mg		-	-	3 - 15 business days*		1,897.00€

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BI-2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well... more

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Product information "BI-2536"

BI-2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. BI-2536 has an IC50 of 0.83 and 25 nM with PLK1 and BRD4 inhibitor, respectively. BI-2536 also blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-ß) gene transcription. It also shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.

Keywords:	BI2536, BI 2536,
Supplier:	BPS Bioscience
Supplier-Nr:	82062

Properties

Application:	pan-BET (bromodomain and extra-terminal motif) family inhibitor, Plk1 inhibitor
MW:	521,7 D
Formula:	C28H39N7O3

Database Information

CAS :	755038-02-9\| Matching products
KEGG ID :	K06631 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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