BG45

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively). At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.Formal Name: N-(2-aminophenyl)-2-pyrazinecarboxamide. CAS Number: 926259-99-6. Molecular Formula: C11H10N4O. Formula Weight: 214.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 267 nm. SMILES: NC1=C(NC(C2=NC=CN=C2)=O)C=CC=C1. InChi Code: InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16). InChi Key: LMWPVSNHKACEKW-UHFFFAOYSA-N.