beta-Elemonic Acid

beta-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro. beta-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. beta-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.Formal Name: 3-oxo-(13alpha,14beta,17alpha,20S)-lanosta-8,24-dien-21-oic acid. CAS Number: 28282-25-9. Synonyms: Elemadienonic Acid, 3-Oxotirucallenoic Acid, 3-oxo Tirucallic Acid. Molecular Formula: C30H46O3. Formula Weight: 454.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 5 mg/ml, Ethanol: 5 mg/ml. SMILES: C/C(C)=C/CC[C@H](C(O)=O)[C@]1([H])CC[C@]([C@@]1(C)CC2)(C)C3=C2[C@]4(C)[C@](CC3)([H])C(C)(C)C(CC4)=O. InChi Code: InChI=1S/C30H46O3/c1-19(2)9-8-10-20(26(32)33)21-13-17-30(7)23-11-12-24-27(3,4)25(31)15-16-28(24,5)22(23)14-18-29(21,30)6/h9,20-21,24H,8,10-18H2,1-7H3,(H,32,33)/t20-,21-,24-,28+,29-,30+/m0/s1. InChi Key: XLPAINGDLCDYQV-SDTWUMECSA-N. Origin: Plant/Boswelli aserrata.