Besifovir

Besifovir is an antiviral nucleoside derivative of 2'-deoxyguanosine 5'-monophosphate (dGMP, Cay-16408). It reduces viral replication in Huh7 cells infected with wild-type hepatitis B virus (HBV) or a lamivudine-resistant HBV clinical isolate (IC50s = 3.5 and 7.47 µM, respectively). Besifovir also reduces viral replication in Huh7 cells infected with an entecavir-resistant HBV clinical isolate (IC50 = 26 µM).Formal Name: P-[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-phosphonic acid. CAS Number: 441785-25-7. Synonyms: BFV. Molecular Formula: C10H14N5O4P. Formula Weight: 299.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 226 nm. SMILES: NC1=NC2=C(C=N1)N=CN2CC3(CC3)OCP(O)(O)=O. InChi Code: InChI=1S/C10H14N5O4P/c11-9-12-3-7-8(14-9)15(5-13-7)4-10(1-2-10)19-6-20(16,17)18/h3,5H,1-2,4,6H2,(H2,11,12,14)(H2,16,17,18). InChi Key: KDNSSKPZBDNJDF-UHFFFAOYSA-N.