Benzbromarone

Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption. It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents. Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.Formal Name: (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-methanone. CAS Number: 3562-84-3. Synonyms: MJ10061, NSC 85433. Molecular Formula: C17H12Br2O3. Formula Weight: 424.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL, DMSO: 20 mg/mL, Ethanol: 3 mg/mL. lambdamax: 238, 277, 282 nm. SMILES: BrC1=C(O)C(Br)=CC(C(C2=C(CC)OC3=C2C=CC=C3)=O)=C1. InChi Code: InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3. InChi Key: WHQCHUCQKNIQEC-UHFFFAOYSA-N.