52 products were found matching "K17719"!

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme's activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 µM) that demonstrates at least 100-fold selectivity over other CYP450...

Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption. It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents. Several analogs of benzabromarone have...

Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 µM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and...

Hydroxy bosentan is an active phase I metabolite of bosentan (Cay-11731) produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM). Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan...

White to off-white solid. Soluble in chloroform. Major naproxen demethylation metabolite. Naproxen demethylation is mediated primarily by CYP2C9. Can be used for assaying naproxen metabolites.

Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib (Cay-10008672). It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9.Formal Name: 4-[1-[4-(aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-benzoic acid. CAS Number: 170571-01-4. Molecular...

Methysticin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline methochloride at the gamma-aminobutyric acid (GABA) receptor GABAA at 0.1 µM. Methysticin inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2D6.Formal Name:...

Early screening of drug candidate's potential to induce or inhibit CYP2C9 is a critical step in the drug development process. The CYP2C9 Induction Reporter Assay Kit is a novel method to evaluate CYP2C9 induction by drug candidates. Cayman's CYP2C9 Induction Reporter Assay Kit consists of a 96-well plate coated with...

7-hydroxy Warfarin is a metabolite of (-)-warfarin (Cay-13531), which is a more potent vitamin K antagonist than (+)-warfarin (Cay-13526). Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9). Stereoselective metabolism also occurs, and CYP2C9 is the primary enzyme responsible for...

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is...

(R)-Mephenytoin is the (R) enantiomer of the anticonvulsant mephenytoin. (R)-Mephenytoin can be demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the active metabolite 5-ethyl-5-phenylhydantoin (nirvanol). The ratio of (S)-mephenytoin (Cay-11913) to (R)-mephenytoin in urine following administration of...