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Human CYP2C9 (Cytochrome P450 2C9) ELISA Kit
Human CYP2C9 (Cytochrome P450 2C9) ELISA Kit

Item number: ELK-ELK7438.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CYP2C9. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CYP2C9....
Keywords: CYPIIC9, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450 MP-4,...
Application: ELISA
Species reactivity: human
365.00€ * From 328.50€ *
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Methysticin
Methysticin

Item number: Cay20258-5

Methysticin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline methochloride at the gamma-aminobutyric acid (GABA) receptor GABAA at 0.1 µM. Methysticin inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2D6.Formal Name:...
Keywords: Kavatin, NSC 112158, (6R)-6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
Application: CYP2C9 & CYP2D6 inhibitor
CAS 495-85-2
MW: 274.3 D
From 43.00€ *
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trans-carboxy Glimepiride
trans-carboxy Glimepiride

Item number: Cay34277-1

trans-carboxy Glimepiride is a metabolite of the sulfonylurea glimepiride (Cay-12090). It is formed from glimepiride in a two-step process mediated by the cytochrome P450 (CYP) isoform CYP2C9 and cytosolic enzymes.Formal Name:...
Keywords: trans-4-[[[[[4-[2-[[(3-ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulfonyl]amino]carbonyl...
Application: Glimepiride metabolite
CAS 1217739-04-2
MW: 520.6 D
282.00€ *
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Sulfaphenazole
Sulfaphenazole

Item number: Cay14844-250

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme's activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 µM) that demonstrates at least 100-fold selectivity over other CYP450...
Keywords: Depocid, Depotsulfonamide, Plisulfan, Raziosulfa, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide
Application: CYP2C9 inhibitor
CAS 526-08-9
MW: 314.4 D
From 158.00€ *
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Benzbromarone
Benzbromarone

Item number: Cay19768-500

Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption. It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents. Several analogs of benzabromarone have...
Keywords: MJ10061, NSC 85433, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-methanone
Application: Urate anion transporter inhibitor, CYP2C9 inhibitor
CAS 3562-84-3
MW: 424.1 D
From 43.00€ *
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Linderane
Linderane

Item number: Cay27479-10

Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 µM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and...
Keywords: (1aS,4E,10S,10aS)-3,6,10,10a-tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one
Application: CYP2C9 inhibitor
CAS 13476-25-0
MW: 260.3 D
From 60.00€ *
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Hydroxy Bosentan
Hydroxy Bosentan

Item number: Cay22366-5

Hydroxy bosentan is an active phase I metabolite of bosentan (Cay-11731) produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM). Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan...
Keywords: Ro 48-5033, Ro 48-8634,...
Application: Active metabolite, Endothelin receptor antagonist
CAS 253688-60-7
MW: 567.6 D
From 155.00€ *
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(S)-O-Desmethylnaproxen
(S)-O-Desmethylnaproxen

Item number: CDX-D0390-M010

White to off-white solid. Soluble in chloroform. Major naproxen demethylation metabolite. Naproxen demethylation is mediated primarily by CYP2C9. Can be used for assaying naproxen metabolites.
Keywords: (S)-6-Hydroxy-alpha-methyl-2-naphthaleneacetic acid, (S)-6-O-Desmethylnaproxen
Application: Major naproxen demethylation metabolite
CAS 52079-10-4
MW: 216,2 D
From 183.00€ *
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Celecoxib Carboxylic Acid
Celecoxib Carboxylic Acid

Item number: Cay34062-10

Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib (Cay-10008672). It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9.Formal Name: 4-[1-[4-(aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-benzoic acid. CAS Number: 170571-01-4. Molecular...
Keywords: 4-[1-[4-(aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-benzoic acid
Application: Inactive celecoxib metabolite
CAS 170571-01-4
MW: 411.4 D
From 142.00€ *
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CYP2C9 Induction Reporter Assay Kit
CYP2C9 Induction Reporter Assay Kit

Item number: Cay601120-1

Early screening of drug candidate's potential to induce or inhibit CYP2C9 is a critical step in the drug development process. The CYP2C9 Induction Reporter Assay Kit is a novel method to evaluate CYP2C9 induction by drug candidates. Cayman's CYP2C9 Induction Reporter Assay Kit consists of a 96-well plate coated with...
Keywords: CYP2C9, CYP2C10, CYPIIC9, EC=1.14.13.-, EC=1.14.13.48, EC=1.14.13.80, EC=1.14.13.49, Cytochrome P-450MP, Cytochrome P450...
Application: Reverse transfection reporter assay
621.00€ *
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Human CYP2C9 / Cytochrome P450 2C9 ELISA Kit
Human CYP2C9 / Cytochrome P450 2C9 ELISA Kit

Item number: G-HUFI01541.96

Application: ELISA
Species reactivity: human
641.00€ *
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7-hydroxy Warfarin
7-hydroxy Warfarin

Item number: Cay9000672-1

7-hydroxy Warfarin is a metabolite of (-)-warfarin (Cay-13531), which is a more potent vitamin K antagonist than (+)-warfarin (Cay-13526). Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9). Stereoselective metabolism also occurs, and CYP2C9 is the primary enzyme responsible for...
Keywords: 4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
Application: Metabolite
CAS 17834-03-6
MW: 324.3 D
From 104.00€ *
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