BAY-1895344 (hydrochloride)

BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) kinase that inhibits proliferation in a panel of human tumor cell lines (mean IC50 = 78 nM). It halts tumor growth in ovarian and colorectal mouse xenograft models and induces complete tumor remission in mantle cell lymphoma mouse xenograft models. BAY-1895344 also exhibits synergistic anti-tumor activity with radium-223 in a mouse xenograft model of castration-resistant prostate cancer bone metastases.Formal Name: 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine, monohydrochloride. Molecular Formula: C20H21N7O . HCl. Formula Weight: 411.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Water: 30 mg/ml. lambdamax: 256, 296, 431 nm. SMILES: C[C@H](COCC1)N1C2=NC3=C(C4=NNC=C4)N=CC=C3C(C5=CC=NN5C)=C2.Cl. InChi Code: InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16,/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25),1H/t13-,/m1./s1. InChi Key: KWQNBYGUBHMRPY-BTQNPOSSSA-N.