Baloxavir Marboxil

Baloxavir marboxil is a prodrug form of the antiviral and influenza virus cap-dependent endonuclease (CEN) inhibitor baloxavir acid. It inhibits influenza CEN and CEN/RNA-dependent RNA polymerase (CEN/RdRp) activity in cell-free assays (IC50s = 530 and 340 nM, respectively). Baloxavir marboxil prevents mortality in a mouse model of influenza A and B viral infection when administered at a dose of 5 or 50 mg/kg twice in a single day. It also reduces lung viral titers, body weight loss, and mortality in a mouse model of influenza A and B viral infection when administered 72 hours post-infection at 50 mg/kg. Formulations containing baloxavir marboxil have been used in the early treatment of uncomplicated influenza.Formal Name: [[(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]-carbonic acid, methyl ester. CAS Number: 1985606-14-1. Synonyms: BXM, S-033188. Molecular Formula: C27H23F2N3O7S. Formula Weight: 571.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml. lambdamax: 259 nm. SMILES: O=C1N(CCOC2)[C@]2([H])N([C@H]3C4=CC=C(F)C(F)=C4CSC5=CC=CC=C53)N(C=CC6=O)C1=C6OCOC(OC)=O. InChi Code: InChI=1S/C27H23F2N3O7S/c1-36-27(35)39-14-38-25-19(33)8-9-31-24(25)26(34)30-10-11-37-12-21(30)32(31)23-15-6-7-18(28)22(29)17(15)13-40-20-5-3-2-4-16(20)23/h2-9,21,23H,10-14H2,1H3/t21-,23+/m1/s1. InChi Key: RZVPBGBYGMDSBG-GGAORHGYSA-N.