Bacopaside X

Bacopaside X is a triterpenoid saponin that has been found in B. monniera and has antifungal and anticancer activities. It inhibits the growth of the fungi C. albicans, C. neoformans, and A. fumigatus (MIC = 50 µg/ml for all). Bacopaside X decreases the proliferation of MDA-MB-231, SHG44, HCT8, A549, and PC3M cancer cell lines with IC50 values of 14.3, 15.9, 9.8, 9.7, and 10.1 µM, respectively. It reduces tumor growth by 84.13% in an S180 sarcoma mouse allograft model when administered at a dose of 50 µmol/kg.Formal Name: (3beta,16beta,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-alpha-L-arabinofuranosyl-(1->2)-O-[beta-D-glucopyranosyl-(1->3)]-alpha-L-arabinopyranoside. CAS Number: 94443-88-6. Synonyms: Bacopaside VII, Jujubogenin isomer of Bacopasaponin C. Molecular Formula: C46H74O17. Formula Weight: 899.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: C[C@]1(CC[C@@]2([H])C3(C)C)[C@@]4(CO[C@]5(C4)[C@]6([H])[C@](O)(C)C[C@H](/C=C(C)/C)O5)[C@]6([H])CC[C@]1([H])[C@]2(CC[C@@H]3O[C@H](OC[C@H](O)[C@@H]7O[C@@H]([C@@H]([C@@H](O)[C@@H]8O)O)O[C@@H]8CO)[C@@H]7O[C@H]9[C@H](O)[C@@H](O)[C@H](CO)O9)C. InChi Code: InChI=1S/C46H74O17/c1-21(2)14-22-15-44(7,55)37-23-8-9-28-42(5)12-11-29(41(3,4)27(42)10-13-43(28,6)45(23)19-46(37,63-22)57-20-45)60-40-36(62-38-33(53)31(51)26(17-48)59-38)35(24(49)18-56-40)61-39-34(54)32(52)30(50)25(16-47)58-39/h14,22-40,47-55H,8-13,15-20H2,1-7H3/t22-,23+,24-,25+,26-,27-,28+,29-,30+,31-,32-,33+,34+,35-,36+,37-,38-,39-,40-,42-,43+,44-,45-,46-/m0/s1. InChi Key: RANQPHKSRUUPKK-GPUGMLHBSA-N. Origin: Plant/Bacopa monnieri.