AZD 4604

AZD 4604 is a JAK1 inhibitor (IC50 = 0.54 nM). It is selective for JAK1 over JAK2 and JAK3 (IC50s = 686 and >10,000 nM, respectively), as well as tyrosine kinase 2 (TYK2, IC50 = 657 nM). AZD 4604 inhibits IL-4- or IL-13-induced phosphorylation of STAT6 in U937 cells (IC50s = 24 and 34 nM, respectively). In vivo, AZD 4604 (1 mg/kg) reduces lung STAT3 and STAT5 phosphorylation in a rat model of ovalbumin-induced asthma. It also inhibits lung eosinophilia and reduces the late asthmatic response in the same model.Formal Name: N-[3-[5-fluoro-2-[[2-fluoro-3-(methylsulfonyl)phenyl]amino]-4-pyrimidinyl]-1H-indol-7-yl]-alphaR-(methoxymethyl)-4-methyl-1-piperazineacetamide. CAS Number: 2241039-81-4. Synonyms: Londamocitinib. Molecular Formula: C28H31F2N7O4S. Formula Weight: 599.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: FC1=C(C2=CNC3=C2C=CC=C3NC([C@@H](COC)N4CCN(C)CC4)=O)N=C(NC5=C(F)C(S(C)(=O)=O)=CC=C5)N=C1. InChi Code: InChI=1S/C28H31F2N7O4S/c1-36-10-12-37(13-11-36)22(16-41-2)27(38)33-21-8-4-6-17-18(14-31-26(17)21)25-19(29)15-32-28(35-25)34-20-7-5-9-23(24(20)30)42(3,39)40/h4-9,14-15,22,31H,10-13,16H2,1-3H3,(H,33,38)(H,32,34,35)/t22-/m1/s1. InChi Key: JNUZADQZHYFJGW-JOCHJYFZSA-N.