AZ 10606120 (hydrochloride)

AZ 10606120 is an antagonist of the purinergic P2X7 receptor (IC50 = 10 nM). It reduces cell migration and proliferation of PANC-1 pancreatic ductal adenocarcinoma cells when used at a concentration of 10 µM. AZ 10606120 (0.01 µg/kg) reduces cecal slurry-induced impairment of endothelial-dependent relaxation but increases spleen bacterial burden in a mouse model of polymicrobial sepsis.Formal Name: N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-tricyclo[3.3.1.13,7]decane-1-acetamide, dihydrochloride. CAS Number: 607378-18-7. Molecular Formula: C25H34N4O2 . 2HCl. Formula Weight: 495.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Water: soluble. SMILES: O=C(CC12CC3CC(C2)CC(C1)C3)NC4=CC=CC5=NC(NCCNCCO)=CC=C54.Cl.Cl. InChi Code: InChI=1S/C25H34N4O2.2ClH/c30-9-8-26-6-7-27-23-5-4-20-21(28-23)2-1-3-22(20)29-24(31)16-25-13-17-10-18(14-25)12-19(11-17)15-25,,/h1-5,17-19,26,30H,6-16H2,(H,27,28)(H,29,31),2*1H. InChi Key: BVFONFUUWORSPO-UHFFFAOYSA-N.