Avridine

Avridine is a synthetic lipid amine that acts as an adjuvant. Subplantar injection of avridine induces paw swelling, an effect that can be blocked by the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone (Cay-70400) or the alkylating agent cyclophosphamide (Cay-13849), in rats. Avridine induces paw joint tissue destruction, bone and pannus formation, and neutrophil, fibroblast, and osteoclast infiltration in the same model. It also increases the number of CD4+ T and MHC class II+ cells in rat paws when administered at a dose of 1.5 mg/animal. Avridine has been used to induce experimental rheumatoid arthritis in rats.Formal Name: 2,2'-[[3-(dioctadecylamino)propyl]imino]bis-ethanol. CAS Number: 35607-20-6. Synonyms: CP 20,961. Molecular Formula: C43H90N2O2. Formula Weight: 667.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: OCCN(CCO)CCCN(CCCCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCCCC. InChi Code: InChI=1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3. InChi Key: WXNRAKRZUCLRBP-UHFFFAOYSA-N.