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ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen (Cay-70290). It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 µM. ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 µmol/kg. ATB-346 (30 µmol/kg) improves motor function in a mouse model of spinal cord injury.Formal Name: 6-methoxy-alpha-methyl-2-naphthaleneacetic acid, 4-(aminothioxomethyl)phenyl ester. CAS Number: 1226895-20-0. Molecular Formula: C21H19NO3S. Formula Weight: 365.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO:. lambdamax: 231 nm. SMILES: COC1=CC=C2C(C=CC(C(C)C(OC3=CC=C(C(N)=S)C=C3)=O)=C2)=C1. InChi Code: InChI=1S/C21H19NO3S/c1-13(21(23)25-18-8-5-14(6-9-18)20(22)26)15-3-4-17-12-19(24-2)10-7-16(17)11-15/h3-13H,1-2H3,(H2,22,26). InChi Key: YCNMAPLPQYQJFC-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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