Apoptosis Activator 2

Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation. This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 µM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 µM).Formal Name: 1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione. CAS Number: 79183-19-0. Synonyms: AAII, N-(3,4-dichlorobenzyl) Isatin. Molecular Formula: C15H9Cl2NO2. Formula Weight: 306.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 245, 296 nm. SMILES: O=C1C(C2=CC=CC=C2N1CC3=CC=C(Cl)C(Cl)=C3)=O. InChi Code: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2. InChi Key: KGRJPLRFGLMQMV-UHFFFAOYSA-N.