APHS

APHS is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and -2, with IC50 values of 17 and 0.8 µM for human recombinant COX-1 and -2, respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1. APHS acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition.Formal Name: 2-(2-heptynylthio)-phenol acetate. CAS Number: 209125-28-0. Molecular Formula: C15H18O2S. Formula Weight: 262.4. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >14.3 mg/ml, DMSO: >11.1 mg/ml, Ethanol: >12.5 mg/ml, PBS pH 7.2: <20 µg/ml. SMILES: CC(OC1=CC=CC=C1SCC#CCCCC)=O. InChi Code: InChI=1S/C15H18O2S/c1-3-4-5-6-9-12-18-15-11-8-7-10-14(15)17-13(2)16/h7-8,10-11H,3-5,12H2,1-2H3. InChi Key: GXMBHQRROXQUJS-UHFFFAOYSA-N.