Amprenavir-d4

Amprenavir-d4 is intended for use as an internal standard for the quantification of amprenavir (Cay-15369) by GC- or LC-MS. Amprenavir is an inhibitor of HIV protease (Ki = 0.04 nM). It inhibits the cytopathic effects of HIV-1 in MT-4 cells (IC50 = 150 nM). Formulations containing amprenavir have been used in combination with other antiretroviral agents in the treatment of HIV-1 infection.Formal Name: N-[(1S,2R)-3-[[(4-aminophenyl-d4)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid, (3S)-tetrahydro-3-furanyl ester. CAS Number: 2738376-78-6. Synonyms: APV-d4, Prozei-d4. Molecular Formula: C25H31D4N3O6S. Formula Weight: 509.7. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, Methanol: soluble. SMILES: NC1=C([2H])C([2H])=C(S(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC(O[C@H]3CCOC3)=O)CC(C)C)(=O)=O)C([2H])=C1[2H]. InChi Code: InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1/i8D,9D,10D,11D. InChi Key: YMARZQAQMVYCKC-MHVPRHJPSA-N.