Amoxapine

Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM. It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C, respectively), dopamine D2, 3, 4 (Kd = 160 nM for D2), alpha1-adrenergic (Kd = 50 nM), and histamine H1 (Kd = 25 nM) receptors.Formal Name: 2-chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]oxazepine. CAS Number: 14028-44-5. Synonyms: CL-67772. Molecular Formula: C17H16ClN3O. Formula Weight: 313.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 210, 252 nm. SMILES: ClC1=CC2=C(C=C1)OC3=C(C=CC=C3)N=C2N4CCNCC4. InChi Code: InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2. InChi Key: QWGDMFLQWFTERH-UHFFFAOYSA-N.