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Amorolfine is an antifungal. It is active against isolates of T. rubrum, T. mentagrophytes, and C. albicans (MIC90s = 4-15, 4-60, and =30-500 ng/ml, respectively). It inhibits the growth of T. mentagrophytes and T. rubrum by 33.7 and 38.5%, respectively, in an in vitro bovine hoof model of onychomycosis. Amorolfine also decreases the fungal burden in a rabbit model of onychomycosis when used as a 5% nail lacquer. Formulations containing amorolfine have been used in the treatment of fungal infections of the toe- or fingernails.Formal Name: (2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, monohydrochloride. CAS Number: 78613-38-4. Synonyms: Ro 14-4767/002. Molecular Formula: C21H35NO . HCl. Formula Weight: 354.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 213, 219, 279, 318 nm. SMILES: CC(CC1=CC=C(C(C)(C)CC)C=C1)CN2C[C@@H](C)O[C@@H](C)C2.Cl. InChi Code: InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22,/h8-11,16-18H,7,12-15H2,1-6H3,1H/t16?,17-,18+,. InChi Key: XZKWIPVTHGWDCF-KUZYQSSXSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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