Amiodarone-d4 (hydrochloride)

Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone (Cay-15213) by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-beta-hydroxysteroid Delta8Delta7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors alpha and beta (IC50s = 0.6 and 0.65 µM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.Formal Name: (2-butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy-1,1,2,2-d4)-3,5-diiodophenyl)methanone, monohydrochloride. CAS Number: 1216715-80-8. Molecular Formula: C25H25D4I2NO3 . HCl. Formula Weight: 685.8. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. SMILES: CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1Cl. InChi Code: InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3,/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3,1H/i13D2,14D2,. InChi Key: ITPDYQOUSLNIHG-MMJSDMDPSA-N.