AM281

AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively). Structurally, it is an analog of the CB1 inverse agonist rimonabant (Cay-9000484). It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate the potential effects of compounds at CB1. It has also been used to study the membrane localization and cycling of CB1.Formal Name: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide. CAS Number: 202463-68-1. Molecular Formula: C21H19Cl2IN4O2. Formula Weight: 557.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml, DMSO: 1 mg/ml. lambdamax: 249 nm. SMILES: ClC1=CC(Cl)=CC=C1N2C(C3=CC=C(I)C=C3)=C(C)C(C(NN4CCOCC4)=O)=N2. InChi Code: InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29). InChi Key: AJFFBPZYXRNAIC-UHFFFAOYSA-N.