alpha-Spinasterol

alpha-Spinasterol is a bioavailable phytosterol originally isolated from spinach that acts as an antagonist at the transient receptor potential vanilloid type 1 (TRPV1) receptor (IC50 = 1.4 µM). It has antinociceptive effects in a noxious heat-induced pain test and also reduces hyperalgesia and edema in a complete Freund's adjuvant-induced inflammatory pain test in mice at a dose of 0.3 µmol/kg. alpha-Spinastrerol increases the seizure threshold in a dose-dependent manner and reduces depressive-like behavior in mice. It also has anti-inflammatory activity in vivo and inhibits benign prostatic hyperplasia in rats.Formal Name: (3beta,5alpha,22E)-stigmasta-7,22-dien-3-ol. CAS Number: 481-18-5. Synonyms: Bessisterol, Hitodesterol. Molecular Formula: C29H48O. Formula Weight: 412.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, Ethanol: 0.25 mg/mL. SMILES: CC(C)[C@H](CC)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-9,11,19-23,25-27,30H,7,10,12-18H2,1-6H3/b9-8+/t20-,21-,22+,23+,25-,26+,27+,28+,29-/m1/s1. InChi Key: JZVFJDZBLUFKCA-FXIAWGAOSA-N.