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alpha-Arbutin is a glycosylated hydroquinone that has been found in Ericaceae and has diverse biological activities. It inhibits tyrosinase in a cell-free assay (IC50 = 0.48 mM for the mouse enzyme) and the production of melanin in HMV-II melanoma cells when used at a concentration of 0.5 mM. alpha-Arbutin (100 µM) prevents increases in reactive oxygen species (ROS) induced by rotenone (Cay-13995) in SH-SY5Y neuroblastoma cells. It decreases locomotor deficits in a parkin-null transgenic Drosophila model of Parkinson's disease. alpha-Arbutin (30 mM) reduces postprandial plasma glucose levels in mice. It has also been used in the synthesis of alpha-glucosidase inhibitors. Formulations containing alpha-arbutin have been used in cosmetic products as skin lightening agents.Formal Name: 4-hydroxyphenyl alpha-D-glucopyranoside. CAS Number: 84380-01-8. Synonyms: Hydroquinone alpha-Glucoside, Hydroquinone O-alpha-D-Glucopyranoside, 4'-Hydroxyphenyl alpha-Glucoside, 4-Hydroxyphenyl alpha-Glucopyranoside. Molecular Formula: C12H16O7. Formula Weight: 272.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 224 nm. SMILES: O[C@@H]1[C@@H](O)[C@@H](OC2=CC=C(O)C=C2)O[C@H](CO)[C@H]1O. InChi Code: InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12+/m1/s1. InChi Key: BJRNKVDFDLYUGJ-ZIQFBCGOSA-N. Origin: Fermentation (species not specified).
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