alpha-Amyrin

alpha-Amyrin is a triterpenoid that has been found in B. copallifera and has diverse biological activities. It inhibits HIV-1 reverse transcriptase (IC50 = 3.3 µM). alpha-Amyrin inhibits the proliferation of B16 2F2 melanoma cells and LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages (IC50s = 50 and 8.98 µM, respectively). It reduces myeloperoxidase (MPO) activity, indicating a decrease in polymorphonuclear leukocyte (PMN) infiltration, and ear edema induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mice (ID50s = 0.45 and 0.31 mg/ear, respectively).Formal Name: (3beta)-urs-12-en-3-ol. CAS Number: 638-95-9. Synonyms: NSC 114787. Molecular Formula: C30H50O. Formula Weight: 426.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C)[C@@]4([H])[C@@H](C)[C@H](C)CC5. InChi Code: InChI=1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h9,19-20,22-25,31H,10-18H2,1-8H3/t19-,20+,22+,23-,24+,25+,27-,28+,29-,30-/m1/s1. InChi Key: FSLPMRQHCOLESF-SFMCKYFRSA-N. Origin: Plant/Burseraceae.